Immune cell line assays

• Reporter assay (e.g. NF-kB-SEAP)
• THP1,Jurkat,TF-1, Raji cell cytokine release, proliferation

TAK-242 Specific Inhibition toTLR4 but not TLR2 in NF-kB Reporter Cells

The cpd shows specific inhibition against TLR4 but not TLR2 in TLR4- or TLR2-NF-kB-SEAP reporter cell lines Percentage of inhibition upon LPS