In vivo Pain Models

Pain Model Assays

• Acute pain :
  • Physiological (tail flick, hind limb withdrawal)
  • Inflammatory (formalin, carrageenan, post-operative),
  • Visceral (acetic acid induced writhing)
• Chronic pain :
  • Inflammatory pain (CFA, MIA),
  • Nerve injured pain (Chung, CCI, PNL,SNI),
  • Diabetic neuropathy pain (STZ),
  • Chemotherapeutical neuropathy pain;

Readouts

• Thermal: hot plate, Hargreaves, PWL, PWT
• Mechanical: von Frey hairs, Randall-Selitto
• Incapacitance Tester: Weight Bearing
• Behavioral Observation: LABORAS System
• Biomarker collections: blood, CSF, brain, spinal cord, DRG, nerve tissues