In vivo Pain Models
Pain Model Assays
- Acute pain :
- Physiological (tail flick, hind limb withdrawal)
- Inflammatory (formalin, carrageenan, post-operative),
- Visceral (acetic acid induced writhing)
- Chronic pain :
- Inflammatory pain (CFA, MIA),
- Nerve injured pain (Chung, CCI, PNL,SNI),
- Diabetic neuropathy pain (STZ),
- Chemotherapeutical neuropathy pain;
Readouts
- Thermal: hot plate, Hargreaves, PWL, PWT
- Mechanical: von Frey hairs, Randall-Selitto
- Incapacitance Tester: Weight Bearing
- Behavioral Observation: LABORAS System
- Biomarker collections: blood, CSF, brain, spinal cord, DRG, nerve tissues
