Medicinal Chemistry

At ChemPartner, our medicinal chemistry leaders all have over 10 years of international experience solving problems and driving projects forward. We have knowledgeable leaders on the ground in Shanghai, working shoulder-to-shoulder with your medicinal chemistry teams and clients may choose to work with our U.S.-based scientists who can provide dedicated design/leadership and project managemant support to their projects to drive their programs depending on individual discovery research needs. We have a long track record of delivering for our partners at all stages of drug discovery from HTS Triage, Hit Identification, Lead Identification, and Lead Optimization through to pre-clinical.

Hit confirmation

Our company began with synthetic chemistry and we have continuously honed our skills for over a decade. Our chemists and compound management group process 1000+ compounds per week. We use our synthesis skills at every stage of our medicinal chemistry projects. We can quickly and efficiently re-synthesize HTS hits for confirmation and quickly make analogs for series confirmation.

Hit Identification

Pairing our strength in synthetic chemistry with our experience in medicinal chemistry, and working closely with our HTS, FBS and DMPK colleagues, we can quickly identify hits from HTS or FBS campaigns or other starting points of the discovery process. After establishing Hit validity we map out a route to either quickly establish proof of concept in newer projects or triage structural classes in mature targets to identify several classes of Hits. ChemPartner has also recently established its own state of the art Fragment Based Screening service to enable in house hit ID.

Hit-to-Lead

Our chemists and project teams refine Hits into Lead status. Our experienced medicinal chemistry teams focus on the critical path assays to solve issues with potency, selectivity, ADME, etc. to quickly develop compounds into Leads by keeping cycle times low and utilizing our in-house computational and rational drug design strategies.

Lead optimization

Working with Leads, our project leaders focus on hypothesis-driven medicinal chemistry, matched pair techniques, and rational drug design to bring the projects Leads into pre-clinical status. Our biology and DMPK groups have a wide range of in vitro and in vivo assays for rapid analysis, and our project teams work closely together to minimize cycle time to quickly solve any remaining compound issues.

Computational Tools

Our exceptional computational chemistry group has a wide range of tools available to assess many aspects of Hits and Leads using a variety of technigues including both structure or logand based design. From assessing novelty and diversity of screening collections to using property filters to select monomers or establish correlations between physical properties and assay data, our project teams have access to any computational tools and expertise necessary.

Tailored Collaborations

We have extensive experience with many types of collaborations from simple chemistry support through ‘co-piloted’ projects where our partners share design responsibility with us and all the way to ‘set and forget’ where our partners simply provide the target and we take care of the entire project from HTS to identifying a Pre-Clinical compound. The cross-functional capability of ChemPartner allows for fully integrated service projects where we provide the entire discovery research teams in chemistry, biology and ADME. Our U.S.-based team of experienced medicinal chemists takes the integrated service model further by providing a sophisticated design and innovation partner, fully enabled by co-located CADD expertise, who can facilitate project team management and communication to meet the client’s specific requirements. We can add all or any additional experts from biology and DMPK etc.. No matter the collaboration parameters, our partners own all the IP generated from our efforts, and we rigorously guard all IP in a multi-tiered, proactive approach.