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In vitro ADME

Home DMPK / Exploratory Toxicology DMPK / Exploratory Toxicology In vitro ADME

In vitro ADME

Metabolic Stability and Metabolite Identification

  • Liver microsomes
  • Human Hepatocytes
  • S9 fractions
  • Plasma and whole blood
  • Metabolic pathway and metabolites identification

Drug-Drug Interactions

  • CYP450 inhibition:
  • CYP450 induction
  • CYP450 phenotyping

Distribution

  • Plasma protein binding
  • Blood partitioning
  • Caco-2 Permeability studies
  • MDR1-MDCK effective efflux

Physical Chemical Properties

  • Solubility and Log D
  • Chemical stability

In Vitro Toxicity

  • Non-GLP Mini-Ames test
  • hERG

At ChemPartner, we know that rapid turnaround of data generated from in vitro ADME studies is critical to making informed decisions on the drug-like properties of new molecular entities. We offer state-of-the-art instrumentation with supporting bioanalytical laboratories and a broad range of in vitro ADME assays.

Broad Range of In-Vitro ADME Assays

  • Physico-chemical: Kinetic and thermo solubility, Log P, Log D, and pKa
  • Absorption: Caco-2 and MDCK-MDR1, MDCK-BCRP and MDCK-MDR1-BCRP
    • Cell Based assays to look at either passive and active absorption, or efflux characteristics
  • Metabolism: Liver microsomes, S9 fraction, or hepatocytes to determine the half-life or rate of disappearance of parent molecule over time
    • Metabolism: Liver microsomes, S9 fraction, or hepatocytes to determine the half-life or rate of disappearance of parent molecule over time
  • Drug-Drug Interactions: CYP P450 Inhibition, Induction, time dependent inhibition and phenotyping assays to identify compound liabilities and identify potential for drug-drug interactions prior to development
  • Distribution: Protein binding using equilibrium dialysis or ultracentrifugation to look at % bound of molecules
  • In Vitro Tox: hERG and mini-Ames or regular AMES testing
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      • OncoCP Database
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