In vitro ADME

Metabolic Stability and Metabolite Identification

• Liver microsomes
• Human Hepatocytes
• S9 fractions
• Plasma and whole blood
• Metabolic pathway and metabolites identification

Drug-Drug Interactions

• CYP450 inhibition:
• CYP450 induction
• CYP450 phenotyping

Distribution

• Plasma protein binding
• Blood partitioning
• Caco-2 Permeability studies
• MDR1-MDCK effective efflux

Physical Chemical Properties

• Solubility and Log D
• Chemical stability

In Vitro Toxicity

• Non-GLP Mini-Ames test
• hERG