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Integrated Biologics Developability Assessment

<img alt="Integrated Biologics Developability Assessment" width="1080" height="675" data-srcset="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-980x551.jpg 980w, https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-480x270.jpg 480w" data-src="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-1080x675.jpg" data-sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1080px, 100vw" class="lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" /><noscript><img alt="Integrated Biologics Developability Assessment" width="1080" height="675" data-srcset="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-980x551.jpg 980w, https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-480x270.jpg 480w" data-src="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-1080x675.jpg" data-sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1080px, 100vw" class="lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" /><noscript><img alt="Integrated Biologics Developability Assessment" width="1080" height="675" data-srcset="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-980x551.jpg 980w, https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-480x270.jpg 480w" data-src="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-1080x675.jpg" data-sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1080px, 100vw" class="lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" /><noscript><img src="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-1080x675.jpg" alt="Integrated Biologics Developability Assessment" class="" width="1080" height="675" srcset="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-980x551.jpg 980w, https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-480x270.jpg 480w" sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1080px, 100vw" />

Integrated Biologics Developability Assessment

by cstolzerhy | Mar 3, 2021

Potential CDR hot spots analysis Biophysical characterization Short-term stability studies Limited forced degradation studies High concentration possibility assessment

Integrated Biologics Developability Assessment

<img alt="Integrated Biologics Developability Assessment" width="1080" height="675" data-srcset="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-980x551.jpg 980w, https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-480x270.jpg 480w" data-src="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-1080x675.jpg" data-sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1080px, 100vw" class="lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" /><noscript><img alt="Integrated Biologics Developability Assessment" width="1080" height="675" data-srcset="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-980x551.jpg 980w, https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-480x270.jpg 480w" data-src="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-1080x675.jpg" data-sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1080px, 100vw" class="lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" /><noscript><img alt="Integrated Biologics Developability Assessment" width="1080" height="675" data-srcset="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-980x551.jpg 980w, https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-480x270.jpg 480w" data-src="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-1080x675.jpg" data-sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1080px, 100vw" class="lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" /><noscript><img src="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-1080x675.jpg" alt="Integrated Biologics Developability Assessment" class="" width="1080" height="675" srcset="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-980x551.jpg 980w, https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-480x270.jpg 480w" sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1080px, 100vw" />

Pharmacology, PK/PD, and Exploratory Toxicity

by cstolzerhy | Mar 3, 2021

Mouse, rat, monkey SC, IP, IV bolus, IV infusion Bio-analytical development PK/PD modeling and simulation In vitro stability in biological matrices Single dose, repeated dose, dose range finding in rats and monkeys Efficacy studies 160+ cell line xenografts and 270+...

Integrated Biologics Developability Assessment

<img alt="Integrated Biologics Developability Assessment" width="1080" height="675" data-srcset="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-980x551.jpg 980w, https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-480x270.jpg 480w" data-src="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-1080x675.jpg" data-sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1080px, 100vw" class="lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" /><noscript><img alt="Integrated Biologics Developability Assessment" width="1080" height="675" data-srcset="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-980x551.jpg 980w, https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-480x270.jpg 480w" data-src="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-1080x675.jpg" data-sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1080px, 100vw" class="lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" /><noscript><img alt="Integrated Biologics Developability Assessment" width="1080" height="675" data-srcset="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-980x551.jpg 980w, https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-480x270.jpg 480w" data-src="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-1080x675.jpg" data-sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1080px, 100vw" class="lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" /><noscript><img src="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-1080x675.jpg" alt="Integrated Biologics Developability Assessment" class="" width="1080" height="675" srcset="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-980x551.jpg 980w, https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-480x270.jpg 480w" sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1080px, 100vw" />

ADC Release and Stability Testing

by cstolzerhy | Mar 3, 2021

Our capabilities include the following assays: Antigen binding activity determination: ELISA, FACS Drug to Antibody ratio (DAR) determination: UV-Vis, LC-MS, HPLC-HIC, iCIEF, etc. Residues of free drug determination: LC-MS/MS In vitro efficacy and bioactivity...

Integrated Biologics Developability Assessment

<img alt="Integrated Biologics Developability Assessment" width="1080" height="675" data-srcset="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-980x551.jpg 980w, https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-480x270.jpg 480w" data-src="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-1080x675.jpg" data-sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1080px, 100vw" class="lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" /><noscript><img alt="Integrated Biologics Developability Assessment" width="1080" height="675" data-srcset="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-980x551.jpg 980w, https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-480x270.jpg 480w" data-src="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-1080x675.jpg" data-sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1080px, 100vw" class="lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" /><noscript><img alt="Integrated Biologics Developability Assessment" width="1080" height="675" data-srcset="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-980x551.jpg 980w, https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-480x270.jpg 480w" data-src="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-1080x675.jpg" data-sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1080px, 100vw" class="lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" /><noscript><img src="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-1080x675.jpg" alt="Integrated Biologics Developability Assessment" class="" width="1080" height="675" srcset="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-980x551.jpg 980w, https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-480x270.jpg 480w" sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1080px, 100vw" />

Complete Analytical Development Packages with mAb/ADC Harmonization

by cstolzerhy | Mar 3, 2021

Concentration determination: spectrophotometry Endotoxin level determination: LAL method Drug to antibody ratio (DAR) determination: LC-MS, HPLC-HIC, RP-HPLC, etc. Purity determination: SEC/ RP/ HIC-HPLC, SDS-PAGE, etc. Residues of free drug determination: LC-MS/MS...

Integrated Biologics Developability Assessment

<img alt="Integrated Biologics Developability Assessment" width="1080" height="675" data-srcset="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-980x551.jpg 980w, https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-480x270.jpg 480w" data-src="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-1080x675.jpg" data-sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1080px, 100vw" class="lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" /><noscript><img alt="Integrated Biologics Developability Assessment" width="1080" height="675" data-srcset="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-980x551.jpg 980w, https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-480x270.jpg 480w" data-src="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-1080x675.jpg" data-sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1080px, 100vw" class="lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" /><noscript><img alt="Integrated Biologics Developability Assessment" width="1080" height="675" data-srcset="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-980x551.jpg 980w, https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-480x270.jpg 480w" data-src="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-1080x675.jpg" data-sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1080px, 100vw" class="lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" /><noscript><img src="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-1080x675.jpg" alt="Integrated Biologics Developability Assessment" class="" width="1080" height="675" srcset="https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-980x551.jpg 980w, https://chempartner.com/wp-content/uploads/2021/02/Bioligics-discovery-new-2-480x270.jpg 480w" sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1080px, 100vw" />

Case Study on T-DM1 (Kadcyla)

by Sarah Stapleton | Mar 3, 2021

Trastuzumab-DM1 (T-DM1; biosimilar of Kadcyla®) was synthesized and was tested in an in vitro efficacy assay employing an in vivo xenograft model. The following results demonstrate the in-house T-DM1 has comparable tumor inhibition activity and in vivo PK profiles...

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