ChemPartner has conducted 120-150 PK studies per week and served many pharmacokinetics (PK) clients.

• AAALAC and OLAW accredited animal facilities with access to broad ranges of animal species
• State-of-the-art instruments
• Extensive experience in PK model development with comprehensive in vivo techniques such as surgical operation and animal care
• Formulation support for in vivo studies including formulation screening, development, and formulation recommendation for various species and strains
• PK/PD data analysis, modeling, and simulation
• Regulatory filing support

Animal Species

• Mouse, rat, guinea pig, rabbit, dog, monkey, and mini pig

Dose Route

• IV, PO, SC, IP, IM, IV infusion, SC infusion, intranasal (IN), intratracheal (IT) and intracerebral ventricular (ICV), rectal, AZ pump, topical administration etc.

Sampling

• Tail vein, jugular vein, facial vein, submandibular, CSF (cisternae; spinal cord), tear, lymph, all tissues etc.

Comprehensive Surgery Techniques

• Portal vein cannulation
• Mesenteric lymph duct cannulation
• Bile duct cannulation (rat, dog, and monkey)
• Intraduodenal administration
• Terminal CSF collection (mice) and survival CSF collection (rat, mini pigs, dog, and monkey)

Biological Matrix

• Blood, plasma, urine, tissue, CSF, brain, sciatic nerve, DRG, lymph node, bone marrow and all other tissues.

Formulation Development

• Clear solution strategy for IV dosing
• Suspension formulation strategy for chronic toxicity study
• Simulated intestinal fluid (SIF) and simulated gastric fluid (SGF) dilution study for in vivo precipitation and super-saturation prediction
• Advanced formulation approach (microsuspension, nanosuspension or solid dispersion)