Ion Channel Targets

• Voltage-gated Ion Channels

• (K+) hERG

• (Na+) Nav 1.5, Nav 1.7, Nav 1.1

• Ligand-gated Ion Channels

• TRP Family (TRPV1, V3, C6)

• P2X Family (P2X3, 4, 7)

• GABAaR (1α, 2β, γ2)

• GluR (AMPA, NMDA) Family

In Vitro and Ex Vivo CNS Biomarkers

• High content image analysis system for neurites

• ELISA assays of neurofilament light protein/progranulin for neuronal degeration

• Neural histology with confocal microscope, PSD95/SV2A, golgi staining

• AAV carried gene expression in cochlea and ex plant

Electrophysiology Platforms

• Transient/stable cell lines

• Primary cultural of DRG, hippocampal, cortical neurons

• Ex vivo brain slices for

• Hippocampus (CA1, CA3, DG)

• Frontal cortex

• Cortex-striatum

• N Accumbens

• Amygdala

• Interpeduncular nucleus

• LTP/LTD or neuronal excitability in:




• Automated Qpatch-48

• Manual patch clamp EPC10 USB, 700B

• Multi-electrode array MED64 system