In addition to assay development and compound profiling, ChemPartner’s in vitro biology team has the robust expertise related to the enzymology necessary to conduct in-depth research on the mechanism of action (MoA) for compounds, including reversibility studies, competition studies, and kinetic analysis (Ki, kon, koff, kinact determination).

Kinetic Analysis

Time-dependent Inhibition

Slow-off vs Irreversible Cmpds

Ki, kinact Determination

Modality of Inhibition

Competitive

Non-Competitive

Un-Competitive