ServicesTranslational BiologyIn Vitro PharmacologyTarget-Specific AssaysAntibody Target Specific Assays
Antibody Target Specific Assays
ID | Target | Receptor Ligand Binding Blocking | Cell-based Functional Readout |
1 | PD1 | PD1/PD-L1 PD1/PD-L2 | T cell activation (PBMC + CHOK1/OS8/PD-L1) Mixed Lymphocyte Reaction Jurkat NFAT luciferase reporter assay |
2 | PD-L1 | PD-L1/PD1 PD-L1/B7.1 | T cell activation (PBMC + CHOK1/OS8/PD-L1) Mixed Lymphocyte Reaction Jurkat NFAT luciferase reporter assay |
3 | CTLA4 | CTLA-4/B7.1 CTLA-4/B7.2 | T cell activation (PBMC/SEB) T cell blast / Raji co-culture |
4 | 4-1BB | 4-1BB/4-1BBL | T cell activation (CHOK1-OS8) NFkB luciferase reporter assay |
5 | GITR | GITR/GITRL | T cell activation NFkB luciferase reporter assay |
6 | LAG3 | LAG-3/MHC II LAG-3/FGL1 LAG-3/LSECtin | NFAT luciferase reporter assay T cell activation (PBMC/SEB) Antigen specific T cell activation |
7 | TIM-3 | TIM-3/Phosphatidylserine | T cell activation (PBMC+CHOK1/OS8 + inducer) |
8 | OX40 | OX40/OX40L | T cell activation NFκB reporter assay |
9 | TIGIT | TIGIT/CD155 TIGIT/CD122 | NFAT luciferase reporter assay |
10 | NKG2A | NKG2A/MHC | NK cell mediated cytotoxicity |
11 | CD70 | CD70/CD27 | Cytotoxicity |
12 | CD73 | hCD73 ECD-his | CD73 Enzymatic activity AMP - T cell Suppression Internalization |
13 | CD47 | CD47/SIPRa | Phagocytosis Hemagglutination |
14 | SEMA4D | SEMA4D/Plexin B1 SEMA4D/Plexin B2 | Cell migration Cell detachment |
Your Trusted Partner Starts Here
Let’s talk. We’ll reach out immediately to understand how we can help.