Mixed Lymphocyte Reaction (MLR) Assay


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The MLR assay is considered the ‘gold standard’ T cell functional assay for the test of T cell immune checkpoint inhibitors

  • Dendritic cells co-cultured with allogeneic CD3+ T cells
  • Readouts: IFN-γ and IL-2 production
  • Suitable to test both antibodies and small molecules, as single agents and in combination





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