Neurodegeneration

• Alzheimer’s Disease – 5x Familial AD Transgenic Mice

• Biomarkers, pathology, EEG, behavioral tests, LTP in brain slice

• Parkinson’s Disease – 6-OHDA Rats

• Apomorphine or L-DOPA challenged rotation

• L-DOPA induced dyskinesia in 6-OHDA rats

• Reserpine-induced dyskinesia in rats

• Harmaline/tacrine-induced tremor in mice and rats

• Hearing Loss – Noise/Chemical-Induced

• Inner ear local delivery and sampling

• ABR tuning curve

• Frequency mapping

• Ophthalmic Degeneration Visible Light-induced Retinal Damage, Rodents

• Electroretinography (ERG)

Neuropsychiatry

• Depression

• Forced swim test, rats and mice

• Tail suspension, mice

• Anxiety

• Vogel conflict test, rats

• Marble test, mice

• Elevated plus maze, mice and rats

• Sucrose preference

• Sleep/Wake and Circadian Rhythm

• Polysomnograph

• Spontaneous Activity with vibration pattern recognition

• CNS Safety Pharmacology

• sLMA

• Modified Irwin

• Pharmaco-EEG in rodents and dogs

Pain

• Inflammatory Pain

• CFA-induced, rats

• Formalin-induced, rats

• Visceral Pain

• Acetic acid writhing, rodents

• Neuropathic Pain

• CCI

• SNL

• STZ-induced diabetic neuropathy

• Chemotherapy-induced neuropathy (Vincristine, Paclitaxel)

• Readouts

• Von Frey, Randall-Selito

• Tail flick, hot/cold plate

Epilepsy

• Chemically-induced seizure

• PTZ-induced, mice

• LiCl and pilocarpine-induced status epilepticus, rats

• Electrically-induced seizure

• 6 Hz electroshock-induced, mice

• Maximal electroshock-induced (MES), mice

• Maximal electroshock threshold (MEST), rodents

• Dravet mice: genetic seizure

Rare Disease

• MLD mice

• Twitcher mice

• Fabry mice

Automatic Analysis of Spontaneous Behavior

Laboras Measurement of Formalin-induced Pawlicks

Hindlimb Licking Number (Total)

AAV-GFP Targeted Expression in Cochlea of C57 Mice

 Laser confocal scanning microscopy (LCSM)

Neuropathic Pain

CCl Model

Chung Model