ChemPartner brings awareness about Autoimmune & Autoinflammatory Arthritis on 2025 AiArthritis Day Invisible and misunderstood: how it is to live with an autoimmune disease? “I think the hardest part of having an autoimmune...
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From Mutation to Metastasis: Preclinical Assay Platform for KRAS G12C Targeted Therapy
Three-decade long saga brings promise and breakthrough for better therapies Kirsten rat sarcoma (KRAS) has been long recognized as the most commonly mutated protooncogene, and under active exploration in cancer research for the...
In Vitro Safety Pharmacology: A Roadmap to Safer and More Effective Drugs
In vitro safety pharmacology profiling plays a crucial role in the drug development process by providing essential information about the potential safety and efficacy of new drug candidates. This approach involves conducting experiments in controlled laboratory...
Engineering Smarter ADCs: Novel Linkers for Better Safety and Efficacy
Antibody-drug conjugates (ADCs) are complex therapeutics that link antibodies to cytotoxic payloads, offering a targeted approach to mitigate the systemic toxicity of conventional chemotherapy. Despite rapid progress in ADC engineering, significant challenges remain,...
Targeted Protein Degradation: Bridging the Gap in PROTAC Development
Unlocking the Potential of Targeted Protein Degradation In the realm of novel therapeutics, targeted protein degradation has serendipitously emerged as a game-changer, transforming "undruggable" proteins into viable candidates for therapeutic intervention. By...
Spotlight on Psoriasis – Advanced IL-23 Inhibitor Preclinical Screening Assays for Better Outcomes for Patients
Psoriasis: Patient Impact and the Path to Innovation Psoriasis is more than a skin condition, it is often a lifelong, systemic autoimmune disease that may increase the risk of other serious health complications such as heart disease and diabetes, and have a...
From Neurons to Networks: High-Throughput Epilepsy Models for Translational Neuroscience
The Importance of Preclinical Models in Epilepsy Drug Discovery Epilepsy is a chronic neurological condition affecting more than 50 million people worldwide and one of the most intensely investigated therapeutic areas in neuroscience. Despite many antiepileptic drugs...