Proteolysis targeting chimera (PROTAC) technology was first discovered in 2001, and it has developed rapidly in the past 20 years to become a powerful strategy in drug discovery, especially for undruggable targets/proteins. Currently, more than 10 PROTAC degraders...
Nucleic acids (DNA) are the carriers of genetic information. The central dogma depicts that genetic information (genes) stored in DNA are transcribed into RNA which are then decoded to translate into proteins. A nucleic acid is an oligonucleotide sequence that is...
Carbohydrate chemistry has been a specialized research area at ChemPartner since our founding. We have extensive expertise and solid experience in the synthesis of complex carbohydrates and their conjugates with a proven track record over the last twenty years....
ChemPartner has a comprehensive ADC (Antibody-Drug Conjugate) research and development platform and over a decade of experience. With a robust team specializing in linker-payload design synthesis, antibody discovery, and ADC conjugation as well as in vitro and in vivo...
An essential part of successful drug development is safety; therefore, many companies are now using safety pharmacology and profiling earlier in the drug discovery process to identify and mitigate off-target related adverse drug reactions and achieve optimal...
PK/PD Correlation in SU-DHL-6 CDX Phosphorylation of downstream target Y (PD marker) inversely correlated with the concentration of Compound X in the tumor (PK)
In addition to assay development and compound profiling, ChemPartner’s in vitro biology team has the robust expertise related to the enzymology necessary to conduct in-depth research on the mechanism of action (MoA) for compounds, including reversibility studies,...
ChemPartner’s possesses the world’s leading automated systems and provides customized high-throughput screening services for our clients. These services include the high-throughput biochemical/cellular assay development or assay validation, clients’ library compound...
ChemPartner’s in vitro biology team has extensive experience in assay development and has the capability to provide a variety of customized assays for our customers. Major Assay Technologies: Fluorescence Detection Chemiluminescence Detection FRET/TR-FRET Detection...
