In the dynamic world of biopharmaceutical research, cell line development and banking is pivotal in paving the way for groundbreaking therapies. Cell lines are stable cell cultures developed from a single cell, thus consisting of cells with a uniform genetic makeup....
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Harnessing the Power of Antibody-Drug Conjugates (ADCs) with Expertise and CROs
In the ongoing battle against cancer, antibody-drug conjugates (ADCs) shine as a beacon of hope. These resourceful molecules combine the precision of monoclonal antibodies with the potency of cytotoxic drugs, making them a formidable weapon against drug resistance and...
Choosing the Right Antibody Generation Method: Phage Display, Hybridoma, or Single B Cell Cloning
There have been remarkable advancements in antibody generation technology over the years, offering scientists many techniques to generate antibodies for various applications ranging from discovery research to diagnostics and therapeutics. Three prominent methods for...
Equilibrium Dialysis vs. Ultracentrifugation for In Vitro Protein Binding Assays
In a modern drug discovery setting, in vitro protein binding assays are essential to assess the binding affinity and characteristics of a drug molecule with plasma proteins. Two commonly used methods for in vitro protein binding assays are equilibrium dialysis and...
In Vitro Safety Pharmacology: A Roadmap to Safer and More Effective Drugs
In vitro safety pharmacology profiling plays a crucial role in the drug development process by providing essential information about the potential safety and efficacy of new drug candidates. This approach involves conducting experiments in controlled laboratory...
3 Reasons to Introduce ADME Assays ASAP in Drug Discovery
Modern Drug Discovery Workflows There are several reasons why it is important to introduce in vitro absorption, distribution, metabolism, and excretion (ADME) assays as early as possible into a modern drug discovery workflow, especially for biotech companies. Here are...
In Vivo Intricacies: The Power of Orthotopic and Metastatic Models in Brain Tumor Studies
Brain tumors are a major cause of cancer-related death, and metastatic brain tumors are particularly difficult to treat. Brain tumors pose significant challenges to scientists in terms of understanding their development and progression, and finding effective treatment...
Unlocking Success: Key Factors to Consider When Choosing the Right CDMO/CRO Partner
In order to stay competitive in the biopharmaceutical industry, companies are increasingly turning to outsourcing as a means of gaining an advantage. With the many competing Contract Development and Manufacturing Organizations (CDMOs) and Contract Research...