Peptide Chemistry Services
Peptide Discovery and Development
COMPREHENSIVE PEPTIDE CHEMISTRY SERVICE OFFERING
From peptide medicinal chemistry through complex synthesis and conjugation, ChemPartner’s Peptide Chemistry group work collaboratively to advance peptide-based therapeutic candidates efficiently from concept to development readiness.
PEPTIDE MEDICINAL CHEMISTRY
Our scientific leadership team bring strategic insight to therapeutic peptide discovery and optimization programs:
- Project leaders with extensive experience in peptide discovery across biotech and pharmaceutical environments.
- Expert peptide design, including computational modeling, structure–activity relationship (SAR) analysis, and lead optimization
- Real-time, global communication enabling open consultation, rapid feedback, and transparent project tracking
- Data-driven troubleshooting and strategy development, with iterative review of experimental results
PEPTIDE SYNTHESIS AND ENGINEERING
Core Synthesis Capabilities
We offer extensive expertise in peptide and peptidomimetic synthesis, supported by advanced instrumentation and scalable workflows:
- Linear and library peptide synthesis using multiple automated synthesizers
- Purification and characterization supported by state-of-the-art analytical platforms
- Cyclic peptide and macrocycle libraries, including:
- Multiple disulfide-bridged peptides
- Ring-closing metathesis (RCM) “stapled” peptides
- 1,2,3-triazole cyclic or bridged peptides
- CLIPS cyclic peptides
- Thiol–ether cyclization
- Lactam-bridged peptides
Advanced Modifications and Building Blocks
- Unnatural amino acid and peptoid building block synthesis
- Novel linker synthesis and peptide backbone modifications
- Peptide labeling, including fluorescein, FRET pairs, isotopes, and click handles
- Substrate and functional peptides, including protease inhibitors and warhead-containing peptides
PEPTIDE CONJUGATES AND COMPLEX ASSEMBLIES
- Peptide–drug conjugates (PDCs)
- GalNAc–peptide conjugates
- Folate-conjugated peptides
- Protein and long peptide synthesis – Up to 150 amino acids via ligation strategies
Post-Synthetic Modifications
- PEGylation
- Glycosylation
- Sulfation
- Phosphorylation
- Alkylation
- Lipidation
SUPPORTING CAPABILITIES AND QUALITY CONTROL
- Peptide synthesis scale: up to 20 g
- Unnatural amino acid synthesis scale: up to 20 g
- Purity: up to 99% (upon request)
- Salt forms: TFA, HCl, acetate, NH₄⁺
- Quality control:
- LC–MS
- 2D NMR
- RP-HPLC
- Enantiomeric excess (ee%) measurement
SELECTED EXPERIENCE AND APPLICATIONS
- Synthesis of RDC-related peptidyl linkers and ligands
- GLP 1–related peptides, including sequences exceeding 70 amino acids and modification (e.g. cyclization and lipidation) for optimized pharmacological properties
