We offer multiple assay formats targeting the mAb portion, toxin, and the intact ADC drug. Single Intravenous Pharmacokinetics Study of Antibody Drug Conjugate (#1015) in Cynomolgus Monkey by Using Kadcyla® as ReferenceTarget Mediated ADC Clearance in Cynomolgus...
Mouse, rat, monkey SC, IP, IV bolus, IV infusion Bio-analytical development PK/PD modeling and simulation In vitro stability in biological matrices Single dose, repeated dose, dose range finding in rats and monkeys Efficacy studies 160+ cell line xenografts and 270+...
Our capabilities include the following assays: Antigen binding activity determination: ELISA, FACS Drug to Antibody ratio (DAR) determination: UV-Vis, LC-MS, HPLC-HIC, iCIEF, etc. Residues of free drug determination: LC-MS/MS In vitro efficacy and bioactivity...
Concentration determination: spectrophotometry Endotoxin level determination: LAL method Drug to antibody ratio (DAR) determination: LC-MS, HPLC-HIC, RP-HPLC, etc. Purity determination: SEC/ RP/ HIC-HPLC, SDS-PAGE, etc. Residues of free drug determination: LC-MS/MS...
Trastuzumab-DM1 (T-DM1; biosimilar of Kadcyla®) was synthesized and was tested in an in vitro efficacy assay employing an in vivo xenograft model. The following results demonstrate the in-house T-DM1 has comparable tumor inhibition activity and in vivo PK profiles...
Apart from antibody humanization and antibody discovery from phage display, ChemPartner’s antibody engineering department also offers sequence optimization and affinity maturation services. We provide customized affinity maturation strategies [random mutagenesis...
ChemPartner’s proprietary fully human naïve phage library with diversity ~10^11. Efficient library selection and screening with high-throughput robotics. All V-genes were amplified with high fidelity from diverse healthy donors. Stringent cloning procedures ensure a...
Specific Pathogen Free (SPF) animals and multiple species/strains such as SJL mice and SD rats New Zealand White rabbit are available for immune phage library approach Animal strains with superior immune response to highly conserved and multi-transmembrane protein...
Immunogen and Antigen Preparation Recombinant protein production and cell line development Peptide and compound design and synthesis DNA In vivo transfection Binding Assays and Bioassays Well-established assays Assay development and optimization for hybridoma...
ChemPartner has a top-tier antibody drug conjugate (ADC) team spanning multiple areas, such as antibody development, medicinal chemistry, DMPK, and in vitro/in vivo pharmacology. In addition to individual function service packages, ChemPartner also provides all-in-one...
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