G Protein Coupled Receptors (GPCR), nuclear hormone receptors, ion channels, and transporters are all important drug targets. More than 50% of drugs targets are receptors; therefore, they have become the most important drug target. GPCR targeted drugs have a wide...
The molecular basis of epigenetics, the study of heritable phenotype changes that do not involve alterations in the DNA sequence, mainly includes the modification of DNA and histones, which lead to the up-regulation or down-regulation of the related gene expression....
Kinases play essential roles in cell signal transduction, thereby regulating various physiological functions of cells; therefore, kinases are an essential drug target for many diseases. ChemPartner’s in vitro biology team has established nearly 200 kinase assays by...
800+ Cancer Cell Line Collection for Anti-proliferation Panel Screening >80% of the cell lines are in CCLE panel with genetic annotationsRepresentative of genomic diversity, tissue, and ethnic originsHigh-quality cell panel guaranteed by STR verification and...
Protein Phosphorylation Western blot Cell-based ELISA AlphaScreen SureFire High content analysis NanoBRET FACS Nuclear Translocation Reporter Gene Assay p-Akt Detected by AlphaScreen SureFire AlphaScreen SureFire Technology pAKT473 in Suspension Cells by AlphaScreen...
Validation of Cas9 Expression by Western Blot Validation of Cas9 Expression by FACS Detect Target B Expression by Western Blot in Single KO Clones (Transient Transfection) CRISPR Target Gene Knockout – Phenotypic Study Knockout of PCNA, an essential gene for cell...
Knock down target gene by siRNA pool or individual oligos Taqman or Western blot analysis to confirm the knockdown efficiency at mRNA level or protein level, respectively The effect of tumor cell growth inhibition is monitored by CellTiter Glo cell viability assay...
