On October 5, 2020, the Nobel Assembly at the Karolinska Institute announced the Nobel Prize for Physiology or Medicine went to Harvey J. Alter, Michael Houghton, and Charles M. Rice “for their discovery of hepatitis C virus (HCV).” The worldwide incidence of HCV...
Antibody Generation: Single B Cell Cloning vs. HybridomaDr. Andreas Loos
A total of 33,377 plasma cells were screened from PD-L1-immunized mice and the secreted antibodies were tested for binders to PD-L1 and blockers of the interaction between PD-L1 and PD-1. The screening assays were completed and a total of 35 antibodies (BCC-Abs) that bound PD-L1 and blocked the interaction with PD-1 were identified on the day the mice were sacrificed. Single cell sequencing allowed the team to recover 24 paired VH/VL sequences, of which 23 could be expressed and purified.
What is something at ChemPartner you’re proud of?
I have established many different kinds of cell-based assay platforms and was responsible for. the set up of the CRISPR based library screening platform.
How has your career grown since starting at ChemPartner?
With help from my supervisors, I have been trained from a senior scientist to a principal scientist. And after working on many diverse projects with different team members, I am responsible for the training, supervising & managing of the team.
What is something in our industry or research that is new/exciting/innovative?
There are so many new targets, new platforms, and new technologies.
What’s a fun fact about you/something people don’t know?
I am learning to cook from the experts in Bilibili.
Cell Biology at ChemPartner
- Target Validation
- Cell-based Assays
- Cancer Cell Line Collection
Chat with a Scientist
Gileadʹs antiviral drug remdesivir has been catapulted to the limelight as the only FDA-approved treatment of coronavirus Covid-19 for emergency use thus far. On April 29, 2020, preliminary clinical trials indicated that the drug has shown some efficacy. While...
Meeting Chiral Separation Efficiency Needs in Pharmaceutical Discovery with Supercritical Fluid Chromatography
Supercritical fluid chromatography (SFC) is now a well-established tool incorporated into the small molecule drug development strategy for organizations of all types and sizes. Its imprint is almost surely on the history of development of any new advanced chiral drug...
1F & 3F, Block A
2829 JinKe Road
Zhangjiang Hi-Tech Park
PuDong New Area
Shanghai China, 201203