It is critical to isolate unique isomers for targeted structural design and accurate assay readouts in small molecule development. Chiral intermediate or final compound single enantiomer isolation is necessary for key assays. Where chiral synthesis is challenging or...
A recently published article entitled Ex vivo engineered human plasma cellsexhibit robust protein secretion and long-term engraftment in vivo1 shows that a subset of in vitro cultured plasma B cells can take on characteristics of long-lived natural plasma B cells. Due...
On October 5, 2020, the Nobel Assembly at the Karolinska Institute announced the Nobel Prize for Physiology or Medicine went to Harvey J. Alter, Michael Houghton, and Charles M. Rice “for their discovery of hepatitis C virus (HCV).” The worldwide incidence of HCV...
Gileadʹs antiviral drug remdesivir has been catapulted to the limelight as the only FDA-approved treatment of coronavirus Covid-19 for emergency use thus far. On April 29, 2020, preliminary clinical trials indicated that the drug has shown some efficacy. While...
Supercritical fluid chromatography (SFC) is now a well-established tool incorporated into the small molecule drug development strategy for organizations of all types and sizes. Its imprint is almost surely on the history of development of any new advanced chiral drug...
When it comes to finding new chemical matter to engage biological targets, fragment-based screening (FBS) offers a number of advantages over traditional high-throughput screening (HTS). The success of this approach has resulted in a growing list of molecules advancing...
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