In Vitro Pharmacology Safety Panel

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An essential part of successful drug development is safety; therefore, many companies are now using safety pharmacology and profiling earlier in the drug discovery process to identify and mitigate off-target related adverse drug reactions and achieve optimal specificity for compounds.

ChemPartner’s in vitro pharmacology safety functional panel includes 47 targets with 78 assays (readouts) that can provide more information about a compound’s function than a standard safety panel that only provides binding information.

Safety Screen Functional Panels

Target Class
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
GPCR
Ion channel
Ion channel
Ion channel
Ion channel
Ion channel
Ion channel
Ion channel
Ion channel
Kinase
Kinase
Kinase
Kinase
Enzyme
Enzyme
Enzyme
Enzyme
Enzyme
Enzyme
NHR
NHR
Transporter
Transporter
Transporter
Target ID
ADORA2A
ADRA1A
ADRA2A
ADRB1
ADRB2
AVPR1A
CB1
CB2
CCKA
D1
D2S
ETA
H1
H2
5HT1A
5HT1B
5HT2A
5HT2B
M1
M2
M3
OPRD1
OPRK1
OPRM1
Cav1.2
GABAA
hERG
5-HT3
KCNQ1
CHRNA4/CHRNB2
Nav1.5
GRIN1/GRIN2B
INSR
LCK
ROCK1
VEGFR2
COX1
COX2
AChE
MAO-A
PDE3A
PDE4D2
AR
GR
DAT
NET
SERT
Target Description
Adenosine A2A Receptor
Alpha-1-adrenergic receptor
Alpha-2-adrenergic receptor
Beta-1 Adrenergic Receptor
Beta-2 Adrenergic Receptor
Arginine Vasopressin Receptor 1A
Cannabinoid Type 1 Receptor
Cannabinoid Type 2 Receptor
Cholecystokinin A Receptor
Dopamine D1 Receptor
Dopamine D2 Receptor
Endothelin Receptor Type A
Histamine H1 receptor
Histamine H2 receptor
5-HT1A Receptor
5-HT1B Receptor
5-HT2A Receptor
5-HT2B Receptor
Muscarinic Acetylcholine M1 Receptor
Muscarinic Acetylcholine M2 Receptor
Cholinergic/Acetylcholine M3 Receptor
Delta-opioid Receptor
Kappa-opioid Receptor
Mu-opioid Receptor
Calcium channel
GABA receptor
Potassium channel
Serotonin receptor
Potassium channel
Nicotinic channel
Sodium channel
Glutamate channel
INSR
LCK
ROCK1
VEGFR2
COX1
COX2
AChE
MAO-A
PDE3A
PDE4D2
AR
GR
Dopamine Transporter
Norepinephrine Transporter
5-HT Transporter
Assay Sub-type
Calcium Flux
Calcium Flux
cAMP
cAMP
cAMP
Calcium Flux
Calcium Flux
Calcium Flux
Calcium Flux
cAMP
cAMP
Calcium Flux
Calcium Flux
Calcium Flux
cAMP
cAMP
Calcium Flux
Calcium Flux
Calcium Flux
cAMP
Calcium Flux
cAMP
cAMP
cAMP
Cell Based
Cell Based
Cell Based
Cell Based
Cell Based
Cell Based
Cell Based
Cell Based
Enzymatic
Enzymatic
Enzymatic
Enzymatic
Enzymatic
Enzymatic
Enzymatic
Enzymatic
Enzymatic
Enzymatic
Cell Based
Cell Based
Binding
Binding
Binding
Assay Format
Agonist & Antagonist
Agonist & Antagonist
Agonist & Antagonist
Agonist & Antagonist
Agonist & Antagonist
Agonist & Antagonist
Agonist & Antagonist
Agonist & Antagonist
Agonist & Antagonist
Agonist & Antagonist
Agonist & Antagonist
Agonist & Antagonist
Agonist & Antagonist
Agonist & Antagonist
Agonist & Antagonist
Agonist & Antagonist
Agonist & Antagonist
Agonist & Antagonist
Agonist & Antagonist
Agonist & Antagonist
Agonist & Antagonist
Agonist & Antagonist
Agonist & Antagonist
Agonist & Antagonist
Blocker
Agonist & Antagonist
Blocker
Agonist & Antagonist
Blocker
Agonist & Antagonist
Agonist & Antagonist
Agonist & Antagonist
Inhibitor
Inhibitor
Inhibitor
Inhibitor
Inhibitor
Inhibitor
Inhibitor
Inhibitor
Inhibitor
Inhibitor
Agonist & Antagonist
Agonist & Antagonist
Binder
Binder
Binder

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