We have developed multiple assays targeting the different war heads of the bispecific antibody and the Fc region.
- Similar PK profile in SD rat for both antibodies
- Fast clearance in monkey
Bispecific Ab – Non-specific PK in Rats and Targeted Mediated Disposition in Cyno Monkeys
Purpose: to evaluate the non-linear PK in cyno monkeys and linear PK in SD rats for bispecific antibodies
Study Design
- Dose
- IV Bolus: 5 mg/kg in SD rats
- IV Bolus: 1, 2.5, or 7.5 mg/kg in cyno monkeys
- Sampling
- Serum collection up to 28 days for rats and up to 42 days for cyno monkeys post dosing
SD Rats (n=4)
Cynos (n=3)
