We offer PK analysis and PKPD modeling for monoclonal antibodies with either affinity-based ligand binding assays or LCMS/MS-based quantification.
High Quality In-Life and BA
Purpose: to evaluate PK property of mAb after IV infusion administration in cynomolgus monkeys (n=4/group)
Study Design:
Dose: 4, 6, or 7 mg/kg
Sampling: Serum collection for 9 time points till 25 post dosing
Results: Good differentiation of PK curve at 4, 6, 7 mg/kg dose level
PKPD in NHP – B Cell Depletion in Lymphoma
- Animals were dosed at 10mg/kg IV bolus (N=2).
- Blood samples were collected until day 42 post dosing
- ELISA measurement for Rituxan concentration; FACS analysis for B cell counting
B cell depleted immediately after IV dosing and maintained at low level until 21 days when started to recover
LC-MS/MS Quantification of Humanized mAb
Can be used in:
- Chimeric ab. BA
- Humanized ab. BA
- Human ab. BA
ELISA Quantification of Humanized mAb
Generic/EASYELISA®
- Fast – no extensive method development required
- Saving
- Easy – no antigen required
Antigen Method
Generic Method
